Example of cluster analysis of oesophageal ambulatory manometry

Dr K R. Haylett et al. see  recent AGIP/IPEM presentation  for details:

Contents

This figure shows the clusters as organised on the Kohonen self organising feature map

Similar clusters are positioned close to each other. The three colours show the post cluster classification based on simple wave propagation test on the class mean signals at each transducer. Pink = Full peristalsis, Green = 'Secondary peristalsis*', Blue = Non peristaltic.

*In this study there were no clear examples of ‘idealised secondary peristalsis’ clusters, i.e. peristalsis that originates in the oesophageal body. In practice 'Secondary peristalsis' should be considered as ‘non ideal primary peristalsis’, and was simply defined when there was no delta t between P1 and P2 wave maxima. Mostly, when there was some evidence of peristalsis distally (P2-P3), there was also evidence of initiation or pressure at P1 as can be evidenced from the clusters below.

Plot pie chart showing class distributions

Summary of cluster information

primary = 1062

large - at least one > 20mmHg  = 1062, small - all < 20mmHg  = 0

secondary = 606

large - at least one > 20mmHg  = 498, small - all < 20mmHg  = 108

unclassified = 2983

large - at least one > 20mmHg  = 0, small - all < 20mmHg = 2983

Cluster details

Class 1 - Follow link for full visualisation of cluster details

       wave1std: 3.6789
       wave2std: 5.1562
       wave3std: 7.5327
       wave1max: -15.4179
       wave2max: 22.1478
       wave3max: 42.6499
       wave1min: -28.9441
       wave2min: -3.0638
       wave3min: 9.3985
      wave1diff: 13.5262
      wave2diff: 25.2116
      wave3diff: 33.2513
         clsize: 210
    peristaltic: 'secondary'
           size: 'size > 20mmHg'
Class 2 - Follow link for full visualisation of cluster details

       wave1std: 11.3836
       wave2std: 15.9166
       wave3std: 33.8120
       wave1max: 10.5463
       wave2max: 66.3876
       wave3max: 119.2452
       wave1min: -28.9210
       wave2min: -4.3487
       wave3min: -4.1052
      wave1diff: 39.4672
      wave2diff: 70.7363
      wave3diff: 123.3504
         clsize: 126
    peristaltic: 'primary'
           size: 'size > 20mmHg'
Class 3 - Follow link for full visualisation of cluster details

       wave1std: 10.5185
       wave2std: 15.2065
       wave3std: 26.8602
       wave1max: 13.1594
       wave2max: 65.7134
       wave3max: 94.9451
       wave1min: -24.7560
       wave2min: -2.5326
       wave3min: -5.4633
      wave1diff: 37.9154
      wave2diff: 68.2460
      wave3diff: 100.4083
         clsize: 273
    peristaltic: 'primary'
           size: 'size > 20mmHg'
Class 4- Follow link for full visualisation of cluster details

       wave1std: 10.1430
       wave2std: 14.1286
       wave3std: 20.0181
       wave1max: 17.4283
       wave2max: 64.1835
       wave3max: 74.6738
       wave1min: -20.9794
       wave2min: -1.1772
       wave3min: -6.5229
      wave1diff: 38.4078
      wave2diff: 65.3607
      wave3diff: 81.1967
         clsize: 175
    peristaltic: 'primary'
           size: 'size > 20mmHg'
Class 5 - Follow link for full visualisation of cluster details

       wave1std: 10.3903
       wave2std: 16.3368
       wave3std: 19.6431
       wave1max: 20.2519
       wave2max: 77.1919
       wave3max: 76.1460
       wave1min: -18.1258
       wave2min: 2.8252
       wave3min: -1.2056
      wave1diff: 38.3776
      wave2diff: 74.3666
      wave3diff: 77.3516
         clsize: 113
    peristaltic: 'primary'
           size: 'size > 20mmHg'
Class 6 - Follow link for full visualisation of cluster details

       wave1std: 10.0080
       wave2std: 14.7534
       wave3std: 17.8739
       wave1max: 24.6322
       wave2max: 76.2700
       wave3max: 75.2891
       wave1min: -11.7925
       wave2min: 8.3894
       wave3min: 8.1872
      wave1diff: 36.4247
      wave2diff: 67.8806
      wave3diff: 67.1019
         clsize: 210
    peristaltic: 'primary'
           size: 'size > 20mmHg'
Class 7 - Follow link for full visualisation of cluster details

       wave1std: 2.9208
       wave2std: 3.2185
       wave3std: 4.0821
       wave1max: -15.4106
       wave2max: 14.2254
       wave3max: 13.1100
       wave1min: -29.4146
       wave2min: -3.4646
       wave3min: -1.4755
      wave1diff: 14.0041
      wave2diff: 17.6900
      wave3diff: 14.5855
         clsize: 108
    peristaltic: 'secondary'
           size: 'all < 20mmHg'
Class 8 - Follow link for full visualisation of cluster details

       wave1std: 5.2385
       wave2std: 7.1820
       wave3std: 10.0846
       wave1max: -7.1554
       wave2max: 35.2775
       wave3max: 32.2998
       wave1min: -25.0931
       wave2min: -2.5173
       wave3min: -6.2019
      wave1diff: 17.9377
      wave2diff: 37.7948
      wave3diff: 38.5017
         clsize: 48
    peristaltic: 'secondary'
           size: 'size > 20mmHg'
Class 9 - Follow link for full visualisation of cluster details

       wave1std: 5.1275
       wave2std: 7.1143
       wave3std: 9.7492
       wave1max: -2.3010
       wave2max: 36.1353
       wave3max: 37.4291
       wave1min: -22.3857
       wave2min: -0.3306
       wave3min: -5.2762
      wave1diff: 20.0847
      wave2diff: 36.4659
      wave3diff: 42.7053
         clsize: 87
    peristaltic: 'primary'
           size: 'size > 20mmHg'
Class 10 - Follow link for full visualisation of cluster details

       wave1std: 4.3903
       wave2std: 5.3826
       wave3std: 7.2334
       wave1max: -3.4132
       wave2max: 29.5932
       wave3max: 29.0549
       wave1min: -20.1913
       wave2min: 2.3112
       wave3min: -2.3881
      wave1diff: 16.7781
      wave2diff: 27.2821
      wave3diff: 31.4429
         clsize: 78
    peristaltic: 'primary'
           size: 'size > 20mmHg'
Class 11 - Follow link for full visualisation of cluster details

       wave1std: 4.4899
       wave2std: 5.5118
       wave3std: 6.4853
       wave1max: 2.7901
       wave2max: 35.3567
       wave3max: 28.2708
       wave1min: -16.8210
       wave2min: 4.6289
       wave3min: 1.8311
      wave1diff: 19.6111
      wave2diff: 30.7278
      wave3diff: 26.4396
         clsize: 79
    peristaltic: 'secondary'
           size: 'size > 20mmHg'
Class 12 - Follow link for full visualisation of cluster details

       wave1std: 3.0425
       wave2std: 4.4070
       wave3std: 4.5578
       wave1max: 5.0037
       wave2max: 35.8371
       wave3max: 29.1740
       wave1min: -8.7802
       wave2min: 11.3652
       wave3min: 9.4411
      wave1diff: 13.7839
      wave2diff: 24.4719
      wave3diff: 19.7329
         clsize: 161
    peristaltic: 'secondary'
           size: 'size > 20mmHg'
Class 13 - Follow link for full visualisation of cluster details

       wave1std: 1.1942
       wave2std: 1.4377
       wave3std: 1.8140
       wave1max: -22.1322
       wave2max: 5.7952
       wave3max: 0.6505
       wave1min: -29.0822
       wave2min: -2.8132
       wave3min: -7.5662
      wave1diff: 6.9500
      wave2diff: 8.6085
      wave3diff: 8.2167
         clsize: 345
    peristaltic: 'unclassified'
           size: 'all < 20mmHg'
Class 14 - Follow link for full visualisation of cluster details
       wave1std: 2.7559
       wave2std: 2.6364
       wave3std: 2.4422
       wave1max: -12.7269
       wave2max: 15.4772
       wave3max: 6.8995
       wave1min: -25.3269
       wave2min: -0.1323
       wave3min: -5.5749
      wave1diff: 12.6000
      wave2diff: 15.6095
      wave3diff: 12.4744
         clsize: 39
    peristaltic: 'unclassified'
           size: 'all < 20mmHg'
Class 15 - Follow link for full visualisation of cluster details

       wave1std: 1.5122
       wave2std: 1.7212
       wave3std: 1.7661
       wave1max: -16.2695
       wave2max: 11.7976
       wave3max: 8.2447
       wave1min: -23.2526
       wave2min: 2.4111
       wave3min: 1.2447
      wave1diff: 6.9831
      wave2diff: 9.3865
      wave3diff: 7.0000
         clsize: 243
    peristaltic: 'unclassified'
           size: 'all < 20mmHg'
Class 16 - Follow link for full visualisation of cluster details
 
       wave1std: 1.0814
       wave2std: 1.3981
       wave3std: 1.4318
       wave1max: -14.5333
       wave2max: 13.1121
       wave3max: 11.1544
       wave1min: -19.5555
       wave2min: 5.2001
       wave3min: 4.7928
      wave1diff: 5.0222
      wave2diff: 7.9119
      wave3diff: 6.3616
         clsize: 180
    peristaltic: 'unclassified'
           size: 'all < 20mmHg'
Class 17 - Follow link for full visualisation of cluster details

       wave1std: 1.3794
       wave2std: 2.4669
       wave3std: 1.6398
       wave1max: -8.8834
       wave2max: 20.8516
       wave3max: 13.3738
       wave1min: -17.0601
       wave2min: 6.8565
       wave3min: 4.9895
      wave1diff: 8.1767
      wave2diff: 13.9951
      wave3diff: 8.3843
         clsize: 95
    peristaltic: 'unclassified'
           size: 'all < 20mmHg'
Class 18 - Follow link for full visualisation of cluster details 

       wave1std: 1.0310
       wave2std: 1.9428
       wave3std: 1.1981
       wave1max: -4.9438
       wave2max: 23.8130
       wave3max: 15.8163
       wave1min: -12.7617
       wave2min: 9.9841
       wave3min: 7.6205
      wave1diff: 7.8179
      wave2diff: 13.8290
      wave3diff: 8.1957
         clsize: 128
    peristaltic: 'unclassified'
           size: 'all < 20mmHg'
Class 19

       wave1std: 1.1971
       wave2std: 1.6697
       wave3std: 1.3743
       wave1max: -18.2076
       wave2max: 7.0225
       wave3max: -2.3766
       wave1min: -24.4778
       wave2min: -2.1231
       wave3min: -8.5695
      wave1diff: 6.2702
      wave2diff: 9.1456
      wave3diff: 6.1929
         clsize: 310
    peristaltic: 'unclassified'
           size: 'all < 20mmHg'
Class 20 - Follow link for full visualisation of cluster details
 
       wave1std: 1.4127
       wave2std: 2.0796
       wave3std: 1.6653
       wave1max: -13.3314
       wave2max: 12.0204
       wave3max: 1.3871
       wave1min: -20.9273
       wave2min: 0.1115
       wave3min: -6.0195
      wave1diff: 7.5959
      wave2diff: 11.9089
      wave3diff: 7.4066
         clsize: 251
    peristaltic: 'unclassified'
           size: 'all < 20mmHg'
Class 21

       wave1std: 1.5769
       wave2std: 1.8626
       wave3std: 1.6541
       wave1max: -10.0820
       wave2max: 14.0494
       wave3max: 5.6018
       wave1min: -18.9624
       wave2min: 3.0702
       wave3min: -2.8529
      wave1diff: 8.8804
      wave2diff: 10.9792
      wave3diff: 8.4546
         clsize: 217
    peristaltic: 'unclassified'
           size: 'all < 20mmHg'
Class 22 - Follow link for full visualisation of cluster details

       wave1std: 1.0952
       wave2std: 1.5007
       wave3std: 1.4328
       wave1max: -14.1009
       wave2max: 13.3884
       wave3max: 6.3506
       wave1min: -19.0292
       wave2min: 5.4637
       wave3min: -0.0459
      wave1diff: 4.9284
      wave2diff: 7.9247
      wave3diff: 6.3965
         clsize: 394
    peristaltic: 'unclassified'
           size: 'all < 20mmHg'
Class 23 - Follow link for full visualisation of cluster details

       wave1std: 1.1137
       wave2std: 1.4869
       wave3std: 1.4090
       wave1max: -12.1211
       wave2max: 13.7014
       wave3max: 6.9421
       wave1min: -18.2681
       wave2min: 5.9737
       wave3min: 0.6328
      wave1diff: 6.1470
      wave2diff: 7.7277
      wave3diff: 6.3092
         clsize: 460
    peristaltic: 'unclassified'
           size: 'all < 20mmHg'
Class 24 - Follow link for full visualisation of cluster details

       wave1std: 1.0644
       wave2std: 1.6029
       wave3std: 1.0035
       wave1max: -9.6359
       wave2max: 16.7938
       wave3max: 9.9508
       wave1min: -16.3816
       wave2min: 6.7887
       wave3min: 4.0257
      wave1diff: 6.7457
      wave2diff: 10.0051
      wave3diff: 5.9251
         clsize: 321
    peristaltic: 'unclassified'
           size: 'all < 20mmHg'

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